Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. An official website of the United States government. The site is secure. sclerosing adenosis and Am J Surg. ; Cha, I.; Bauermeister, DE. Cardeosa G. Clinical breast imaging, a patient focused teaching file. No leaf-like architecture is present. Pseudoangiomatous stromal hyperplasia and breast cancer risk.
Clinically , fibroadenomas presents as solitary, freely mobile lump in the breast. Complex fibroadenomas are a fibroadenoma subtype harboring one or more complex features. Most of the time, sclerosing adenosis lacks cytologic atypia. Become a Gold Supporter and see no third-party ads. Bethesda, MD 20894, Web Policies Unauthorized use of these marks is strictly prohibited. ~50% of these tend to be lobular carcinoma in situ (LCIS), ~20% infiltrating lobular carcinoma, ~20%ductal carcinoma in situ (DCIS), and the remaining 10% are infiltrating ductal carcinoma. Please enable it to take advantage of the complete set of features! These tumors are usually benign, but they can come back and cause the breast to look abnormal if not totally removed. When histopathology on core biopsy reveals a higher-risk lesion, such as atypical lobular hyperplasia, excisional biopsy may be indicated to rule out malignancy. hall county inmate list May be hyalinized (dark pink) if infarcted. We further re-assessed detailed characteristics of each FNA smears to identify cytomorphological features of CFA. Multinucleated stromal giant cells in mammary fibroepithelial neoplasms. We histologically re-classified them into two groups: CFA and NCFA. Would you like email updates of new search results? An official website of the United States government. The immunostains used in breast pathology for the . No calcifications are evident. This page was last edited on 5 January 2021, at 19:25. No leaf-like architecture is present. Focally, the lesion approaches the inked margin; partial lesion transection cannot be excluded. Stanford University School of Medicine. It increases in size during pregnancy and tends to regress with age. incidental finding on histologic examination), Amorphous or pleomorphic clustered microcalcifications; architectural distortion or circumscribed to spiculated mass on mammogram (, Associated with increased mammographic breast density (, Heterogeneous echogenicity, irregular and ill defined mass, focal acoustic shadowing may be seen on ultrasound (, Small (< 1 cm) mass with benign kinetics on MRI (, As a single feature, increased risk of cancer of 1.5 - 2x, as seen with proliferative, 2x higher risk of breast cancer with increased, Does not provide further risk stratification in the presence of other proliferative disease / atypical hyperplasias (, Can mimic malignancy clinically and radiologically, 46 year old woman with sclerosing adenosis with mammogram and cytology mimicking malignancy (, 73 year old woman with sclerosing adenosis and coexisting ductal carcinoma in situ (, 82 year old woman with sclerosing adenosis in sentinel axillary lymph nodes (, Presence of sclerosing adenosis alone in a core biopsy does not require surgical excision, Coexisting atypia will typically prompt surgical consultation, Variable depending on extent of involvement and calcifications, May be indistinguishable from surrounding breast tissue, Multinodular, ill defined, cuts with increased resistance due to fibrosis, Gritty due to frequent calcifications but no chalky yellow white foci or streaks as seen in, Circumscribed to ill defined white, fibrotic mass if nodular adenosis / adenosis tumor, Low power: increase in glandular elements plus stromal fibrosis / sclerosis that distorts and compresses glands, Maintains lobular architecture at low power with rounded and well defined nodules, Centrally is more cellular with distorted and compressed ductules; peripherally has more open or dilated ductules, Often has microcalcifications, due to calcification of entrapped secretions, Preservation of luminal epithelium and peripheral myoepithelium (2 cell layer) with surrounding basement membrane, Myoepithelial cells may vary from being prominent to indistinct on routine H&E staining, Myoepithelial cells are readily apparent via immunohistochemistry, even if difficult to identify on H&E, Rarely penetrates walls of blood vessels or perineural spaces, Epithelium may be involved by proliferative, atypical lesions or in situ carcinoma, If involved by atypia or in situ carcinoma, If florid and overtly non-lobulocentric / (pseudo) infiltrative into fat or stroma, Conspicuous myoepithelial cells with attenuated epithelial cells can appear like stands of single cells and mimic invasive lobular carcinoma, Atypical apocrine metaplasia: nuclear atypia / rare mitosis (, Moderate to markedly cellular, with small to large groups of benign epithelial cells in acinar sheets / cohesive groups / tubules and scattered individual epithelial cells, Also small foci of dense hyalinized stroma (, Tubules may have an angular configuration (, Fibrocystic changes including sclerosing adenosis with microcalcifications, Haphazardly distributed glands (lacks lobulocentric pattern), Lacks myoepithelium but has intact basement membrane, Nodular growth may mimic nodular adenosis / adenosis tumor, Uniform, closely packed tubules (lacks significant distortion by fibrosis), May be difficult to morphologically distinguish from florid sclerosing adenosis with marked distortion and/or involvement by atypia or, More widely spaced tubules with single epithelial layer. 3 Giant (juvenile or cellular) fibroadenoma is a . As the name suggests, is typically found in younger patients. Women with complex fibroadenomas may therefore be managed with a conservative approach, similar to the approach now recommended . Tumors >500 g or disproportionally large compared to rest of breast. The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. Degnim AC, Frost MH, Radisky DC, Anderson SS, Vierkant RA, Boughey JC, Pankratz VS, Ghosh K, Hartmann LC, Visscher DW. May be either adult or juvenile type. Can occur at any age, median age of 25 years ( J R Coll Surg Edinb 1988;33:16 ) Juvenile fibroadenoma generally occurs in younger and adolescent patients < 20 years; reported in children at a very young age ( Am J Surg Pathol . 2006 Oct;17(5):233-8. doi: 10.1111/j.1365-2303.2006.00333.x. Small capillary-like structures in the stroma. Giant juvenile fibroadenoma is a variant of fibroadenoma that occurs in children and adolescent age group. Webpathology.com: A Collection of Surgical Pathology Images . FNA smears from CFA cases showed discohesiveness, enlarged nuclei, prominent nucleoli, and fewer myoepithelial cells more often than NCFA. 2022 Apr 9;13(1):71. doi: 10.1186/s13244-022-01214-7. Complex fibroadenoma with sclerosing adenosis (crowded glands in a fibrotic stroma) (hematoxylin-eosin; original magnification 10). Epub 2021 Jul 12 doi: 10.1371/journal.pone.0253764. Check for errors and try again. Robert V Rouse MD
Pane K, Quintavalle C, Nuzzo S, Ingenito F, Roscigno G, Affinito A, Scognamiglio I, Pattanayak B, Gallo E, Accardo A, Thomas G, Minic Z, Berezovski MV, Franzese M, Condorelli G. Int J Mol Sci. -->, Richard L Kempson MD
8600 Rockville Pike In analyses stratified by involution status and PDWA, complex fibroadenoma was not an independent risk marker for breast cancer. sharing sensitive information, make sure youre on a federal Incidence and management of complex fibroadenomas. Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients. .style2 {font-family: Arial, Helvetica, sans-serif}
sharing sensitive information, make sure youre on a federal FNA of CFA can lead to erroneous or indeterminate interpretation, due to proliferative and/or hyperplastic changes of ductal epithelium with or without atypia. Most common benign tumor of the female breast. Complex fibroadenoma is a sub type of fibroadenomaharboring one or more of the following features: Complex fibroadenomas tend to occur in older patients (median age, 47 years) compared with simple fibroadenomas (median age, 28.5 years). Usual ductal hyperplasia is associated with a slight increase in risk (1.5 - 2 times) for subsequent breast cancer. LM. Long-term risk of breast cancer in women with fibroadenoma. Biphasic lesions of the breast. O'Malley, Frances P.; Pinder, Sarah E. (2006). Accessibility No stromal overgrowth is seen. Our study was to determine the select cytologic features that can accurately distinguish FA from PT. A simple fibroadenoma does not raise your risk for breast cancer. 1999 Aug;16(3):235-47. Systematic review of fibroadenoma as a risk factor for breast cancer. They fall under the broad group of "adenomatous breast lesions". Cancer. Chapter 5 looks at special problems in breast cancer including bilateral breast cancer, cancer of the male breast, the unknown primary presenting with axillary lymphadenopathy, Paget's disease of the nipple-areola complex and phyllodes tumour of the breast. atypical ductal hyperplasia, atypical lobular hyperplasia) often as a result of spread from an adjacent lesion, Similar structure but with prominent myxoid stromal change composed of abundant pale, blue-gray extracellular matrix material, Cysts > 3 mm, sclerosing adenosis, epithelial microcalcifications or papillary apocrine metaplasia (, Increased epithelial hyperplasia with gynecomastoid-like micropapillary projections, Usual (adult type) fibroadenoma: biphasic population composed of abundant spindle stromal cells and naked nuclei, epithelium arranged in antler horn clusters or fenestrated honeycomb sheets (, Myxoid fibroadenoma: high cellularity with stroma and epithelium embedded in myxoid background (, Cellular variant of fibroadenoma shows higher rates of mutation in. 1 It is encountered in women usually before the age of 30 (commonly between 10-18 years of age), 2 although its occurrence in postmenopausal women, especially those receiving estrogen replacement therapy has been documented. Glandular elements have at least two cell layers - epithelial and myoepithelial. official website and that any information you provide is encrypted To determine the cytomorphological features of complex type fibroadenoma (CFA), we reviewed fine needle aspiration (FNA) cytology with correlation to its histopathology findings, and compared them with non-complex type fibroadenoma (NCFA). Stroma is generally more sparse than in conventional fibroadenoma. Women with complex fibroadenomas may therefore be managed with a conservative approach, similar to the approach now recommended for women with simple fibroadenomas. In the male breast, fibroepithelial tumors are very rare, . The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. Complex fibroadenomas are often smaller than simple fibroadenomas (1.3 cm compared with 2.5 cm in simple fibroadenomas). The https:// ensures that you are connecting to the Semin Diagn Pathol. biopsy specimens (, Disordered but morphologically normal appearing ducts and lobules, Prominent pericanalicular adenosis-like epithelial proliferation with little intervening stroma, Generally does not form a clinically dominant mass, Individual lobule or few groups of lobules with collagenized interlobular stroma and loss of
2022 Apr 3;23(7):3989. doi: 10.3390/ijms23073989. and transmitted securely. font-weight: bold;
The pictured lesion is sclerosing adenosis, a benign breast lesion characterized by expansion of glands (with preserved 2 cell layers: inner epithelial and outer myoepithelial cells) within the terminal duct lobular unit with distortion by fibrosis / sclerosis. Local excision -- without a large margin. Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of epithelial (ductal) cells along with myoepithelial components, having a malignant potentiality. This model affords the opportunity for investigators to study the process of mammary carcinogenesis over a very short latency and to investigate early events in this process. emailE=('rouse' + '@' + 'stan' + 'ford.edu')
Ann Surg Oncol. Age-related lobular involution and risk of breast cancer. Complex fibroadenomas are often smaller than simple fibroadenomas (1.3 cm compared with 2.5 cm in simple fibroadenomas). The study included women aged 18-85 years from the Mayo Clinic Benign Breast Disease Cohort who underwent excisional breast biopsy from 1967 through 1991. Robert V Rouse MD
[email protected]. This website is intended for pathologists and laboratory personnel but not for patients. Sabate, JM. The term fibroadenoma combines the words "fibroma," meaning a tumor made up of fibrous tissue, and "adenoma," a tumor of gland tissue. (Sep 2005). Disclaimer. 1.5 - 2 times increased risk. In particular, these mutations are restricted to the stromal component. Conclusions: Stanford University School of Medicine
Am J Clin Pathol. It is usually single, but in 20% of cases there are multiple lesions in the same breast or bilaterally. PMC Unauthorized use of these marks is strictly prohibited. A. Stanford CA 94305-5342, Relative risk for development of invasive breast carcinoma, , Circumscribed breast mass composed of benign stromal and epithelial cells, Atypical ductal or lobular hyperplasia may be present, Carcinoma, in situ or invasive, may be present, Lacks significant stromal hypercellularity, Elevated stromal mitotic rate, usually >4-5 per 10 hpf, abnormal forms may be found, May contain poorly circumscribed areas of fibrocystic change, Lobules typically present (may be atrophic), Frequent intracanalicular or tubular glandular proliferation. No stromal overgrowth is seen. }
Complex type; Fibroadenoma; Fine needle aspiration. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. Richard L Kempson MD. A benign gland has two cell layers - myoepithelial and epithelial. Call Us Free: 714-917-9578 . Fibroadenoma is a benign tumor that arises from the epithelium and stroma of terminal duct-lobular unit. Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. "Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision?". 1994 Jul 7;331(1):10-5. Federal government websites often end in .gov or .mil. 2022 Feb;75(2):133-136. doi: 10.1136/jclinpath-2020-207062. The luminal cell is epithelial. Radiology of fibroadenoma. The study included women aged 18-85 years from the Mayo Clinic Benign Breast Disease . and transmitted securely. Complex fibroadenomas tend to occur in older patients (median age, 47 years) compared with simple fibroadenomas (median age, 28.5 years). One definition of "cellular" is: "stromal cells are touching one another". Board review style answer #1. At a mean follow-up of 2 years, we found a low incidence of malignancy in complex fibroadenomas. panel curtains ikea vmware sase pop postbox near me. 8600 Rockville Pike BCDnet: Parallel heterogeneous eight-class classification model of breast pathology. "Radiologic evaluation of breast disorders related to pregnancy and lactation.". government site. Before Oncoplastic Approach to Giant Benign Breast Tumors Presenting as Unilateral Macromastia. Tumors of the Mammary Gland, Atlas of Tumor Pathology, AFIP Third Series, Fascicle 7, 1993. Epub 2010 Jun 22. Minimal mitotic activity is present (2 mitosis/10 HPF, where 1 HPF ~ 0.2376 mm*mm). Breast MRI during pregnancy and lactation: clinical challenges and technical advances. National Library of Medicine H&E stain. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations. Management of fibroadenoma of the breast. 2021 Jan 10;13(1):e12611. Carty NJ, Carter C, Rubin C, Ravichandran D, Royle GT, Taylor I. Ann R Coll Surg Engl. Epub 2014 Feb 8. Analyses were performed overall, within subgroups of involution status, with other demographic characteristics (age, year of biopsy, indication for biopsy, and family history), and with histologic characteristics, including overall impression [nonproliferative disease, proliferative disease without atypia (PDWA), or atypical hyperplasia]. Mori I, Han B, Wang X, Taniguchi E, Nakamura M, Nakamura Y, Bai Y, Kakudo K. Cytopathology. Approximately 16% of fibroadenomas are complex. If it grows to 5 cm or . Raganoonan C, Fairbairn JK, Williams S, Hughes LE. juvenile, complex, myxoid, cellular, tubular adenoma of the breast. 1994 Jul 7;331(1):10-5. Background Fibroepithelial lesions of the breast include fibroadenoma (FA) and phyllodes tumor (PT). May be either adult or juvenile type. However, women with complex fibroadenoma were more likely to have other, concomitant high-risk histologic characteristics (e.g., incomplete involution and PDWA). Home > E. Pathology by systems > Reproductive system > Female genital system > Breast > complex fibroadenoma, Complex fibroadenoma is a sub type of fibroadenoma harbouring one or more of the following features: 8600 Rockville Pike Please enable it to take advantage of the complete set of features! 2001 May;115(5):736-42. doi: 10.1309/F523-FMJV-W886-3J38. Fibroadenoma, abbreviated FA, is a common benign tumour of the breast. 1. Other names for these tumors include phylloides tumor and cystosarcoma phyllodes. HHS Vulnerability Disclosure, Help Maiorano, E.; Albrizio, M. (Dec 1995). Surgical Pathology Criteria
He Q, Cheng G, Ju H PLoS One 2021;16(7):e0253764. Guinebretire, JM. At the time the article was created The Radswiki had no recorded disclosures. Left breast, at 5 o'clock and 4 cm from the nipple, ultrasound core needle biopsy: Breast tissue with pseudoangiomatous stromal hyperplasia, Hemorrhagic, soft, interanastomosing vascular channels containing red blood cells with invasion into breast parenchyma, Papillary endothelial growth and hyperchromatic endothelial cells, Neoplastic clonal tumors with characteristic genetic change (del 13q14) (this can be demonstrated by loss of Rb protein immunohistochemistry in myofibroblastoma), Solid mass of spindle cells which surrounds and involves ducts and lobules, Tumor cells arranged in long fascicles without significant clefting, nuclear, CD34-, CD31-, nuclear beta catenin+, AE1 / AE3+. Histopathology.
We welcome suggestions or questions about using the website. Complex Breast Fibroadenoma; Complex Fibroadenoma; Complex Fibroadenoma of Breast; Complex Fibroadenoma of the Breast: Definition. It is a rare benign rapidly growing breast mass in adolescent females. white/pale +/-hyalinization, typically paucicellular, compression of glandular elements with perserved myoepithelial cells. Fibroadenoma is the most common benign tumor of the female breast. It should be distinguished from other benign masses of the breast by proper evaluation and management. Fibroadenoma. doi: 10.7759/cureus.12611. We consider the term merely descriptive. Breast.
HHS Vulnerability Disclosure, Help However, we cannot answer medical or research questions or give advice. FOIA Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. Careers. Jacobs. 2008;190 (1): 214-8. Complex fibroadenoma is a sub type of fibroadenoma harbouring one or more of the following features: epithelial calcifications papillary apocrine metaplasia sclerosing adenosis and cysts larger than 3 mm. Grossly, the fibroadenomas are small, well-demarcated, . 2010 Dec;17(12):3269-77. doi: 10.1245/s10434-010-1170-5. FOIA Would you like email updates of new search results? "Tubular adenoma of the breast: an immunohistochemical study of ten cases.". Breast cancer risk (observed versus expected) across fibroadenoma levels was assessed through standardized incidence ratios (SIRs) by using age- and calendar-stratified incidence rates from the Iowa Surveillance, Epidemiology, and End Results registry. Complex fibroadenoma with sclerosing adenosis (crowded, Complex fibroadenoma with sclerosing adenosis (crowded glands in a fibrotic stroma) (hematoxylin-eosin; original magnification, MeSH Compression of glandular elements - very commonly seen. The .gov means its official. pathology researchers that rely upon this methodology to perform tissue analysis in research. Powell CM, Cranor ML, Rosen PP. font-family: Arial, Helvetica, sans-serif;
radial scar or papilloma) that is identified on imaging, May show enhancement on magnetic resonance imaging (, Associated with 1.5 - 2 times increased risk for subsequent breast cancer (, Risk may be slightly higher for patients with a positive family history of breast cancer (, Indicator of general breast cancer risk rather than direct precursor lesion, 30 year old woman with immature-like usual ductal hyperplasia in a fibroadenoma (, 75 year old woman with malignant phyllodes tumor with liposarcomatous differentiation and intraductal hyperplasia (, Usual ductal hyperplasia within gynecomastia-like changes of the female breast (, Proliferation of cells of luminal and myoepithelial lineages, occasionally with intermixed apocrine cells, Mild variation in cellular and nuclear size and shape, Relatively small ovoid nuclei with frequent elongated or asymmetrically tapered (pear shaped) forms, Lightly granular euchromatic chromatin and small nucleoli, Frequent longitudinal nuclear grooves (coffee bean-like) and occasional nuclear pseudoinclusions, Many examples demonstrate cellular maturation, where the cells shrink as they progress from a basal location to the center of the proliferation, becoming small and nearly pyknotic, Eosinophilic, nonabundant cytoplasm with indistinct cell borders, Cohesive proliferation with haphazard, jumbled cell arrangement or streaming growth pattern, Fenestrated, solid and occasional micropapillary patterns, Irregular slit-like fenestrations are common, especially along periphery, Cells run parallel to the edges of secondary spaces and do not exhibit a polarized orientation (this contrasts with the cells of atypical ductal hyperplasia and ductal carcinoma in situ, which have apical-basal polarity and radially orient their apical poles toward the spaces), Typically focal in a background of conventional pattern usual ductal hyperplasia, Short stubby papillae of roughly uniform height, Cytologic features of usual ductal hyperplasia, Cellular maturation present, with tips of papillae formed by tight knots of mature cells, Larger immature basal hyperplastic cells predominate or are increased beyond their usual 1 - 2 cell layers and are instead several cell layers thick, Most often encountered in fibroepithelial lesions with cellular stroma, Florid usual ductal hyperplasia can rarely demonstrate central necrosis, Typically occurs within a radial scar / complex sclerosing lesion, nipple adenoma or juvenile papillomatosis, Florid usual ductal hyperplasia within radial scars / complex sclerosing lesions can occasionally have more active appearing nuclei with mild nuclear enlargement, Other cytologic and architectural features of usual ductal hyperplasia remain intact, Sample may be moderately to highly cellular, Sheets and cohesive clusters of bland ductal cells with regular spacing and associated myoepithelial cells (, Lack of significant nuclear overlap / crowding, Ductal cell nuclei with finely granular chromatin and inconspicuous small nucleoli, Naked myoepithelial cell nuclei in the background may be present, Activating mutations in the PI3K / AKT / mTOR pathway may play a role in pathogenesis (, Round to oval nuclei with homogeneous, fine and hyperchromatic chromatin; inconspicuous nucleoli; and smooth nuclear contours, Increased amounts of pale eosinophilic to amphophilic cytoplasm with conspicuous cell borders, Cellular polarization around luminal and secondary spaces, Atypical architectural patterns formed by polarized growth (cribriform spaces, Roman arches, trabecular bars, micropapillae), Moderate nuclear enlargement throughout the proliferation, Abnormal chromatin, which may be hyperchromatic, cleared and clumped or coarsely granular, Solid epithelial proliferation showing marked expansion of multiple circumscribed duct spaces (, Thin fibrovascular cores punctuate the proliferation, with cellular palisading around the cores, Myoepithelial cells often sparse or absent along fibrovascular cores, Nuclei may superficially resemble those in usual ductal hyperplasia but demonstrate greater populational uniformity, are slightly larger and have abnormal chromatin, Often positive for neuroendocrine markers (, No change in risk compared to control populations, HMWCK mosaic positive / ER diffusely positive, HMWCK mosaic positive / ER heterogeneously positive. Complex fibroadenomas may increase the risk of breast cancer. There are no clear cut mammographic or sonographic features that distinguish complex from simple fibroadenomas. Visual survey of surgical pathology with 11,912 high-quality images of benign and malignant neoplasms & related entities. Sclerosing adenosis and risk of breast cancer. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Disclaimer. Complex fibroadenomas are often smaller than simple fibroadenomas (1.3 cm compared with 2.5 cm in simple fibroadenomas). We welcome suggestions or questions about using the website. FOIA Musio F, Mozingo D, Otchy DP. 2020 Dec;53(3):439-441. doi: 10.1055/s-0040-1716187. Molecular pathology. Limite G, Esposito E, Sollazzo V, Ciancia G, Formisano C, Di Micco R, De Rosa D, Forestieri P. BMC Res Notes. Richard L Kempson MD. Arch Pathol Lab Med. N Engl J Med. Diagnosis in short. Percutaneous radiofrequency-assisted excision of fibroadenomas. Calcifications, mediolateral oblique view, Sign up for our What's New in Pathology e-newsletter, Copyright PathologyOutlines.com, Inc. Click, 30150 Telegraph Road, Suite 119, Bingham Farms, Michigan 48025 (USA). Accessibility Results: Materials and methods: Conclusion: Approximately 16% of fibroadenomas are complex. We welcome suggestions or questions about using the website. ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. Complex fibroadenomas are smaller and appear at an older age. (2006) ISBN:0781762677. malignant papillary lesions of the breast. HHS Vulnerability Disclosure, Help government site. Because of their high mobility, they are also referred to as mouse in the breast/breast mouse. 2003 Oct;12(5):302-7. doi: 10.1016/s0960-9776(03)00123-1. Am Surg. Can occur at any age, but most patients are young and in their reproductive age group. Department of Pathology. Although no significant difference was noted in patients' age and tumor size between CFA and NCFA, 5 CFA cases (33.3 %) were accompanied by the presence of carcinoma in the same breast or the contralateral breast while no NCFA cases had carcinoma in the breast. Breast Cancer Res Treat. IHC can aid in visualizing the myoepithelial layer. Florid usual ductal hyperplasia in radial scar, Sign up for our What's New in Pathology e-newsletter, Copyright PathologyOutlines.com, Inc. Click, 30150 Telegraph Road, Suite 119, Bingham Farms, Michigan 48025 (USA). 2013 Sep;41(9):806-11. doi: 10.1002/dc.22914. The border is well-circumscribed where seen. Carcinoma Breast-Like Giant Complex Fibroadenoma: A Clinical Masquerade. ; Holden, JA. "Cellular" is something that can be subjective. Sign up for our What's New in Pathology e-newsletter, Copyright PathologyOutlines.com, Inc. Click, 30150 Telegraph Road, Suite 119, Bingham Farms, Michigan 48025 (USA).